Metformina: liberação imediata x liberação prolongada

Por Vanessa Gervasio e Vivian Fidelis

Referências:

AGGARWAL, Naresh et al. Metformin extended-release versus immediate-release: An international, randomized, double-blind, head-to-head trial in pharmacotherapy-naïve patients with type 2 diabetes. Diabetes Obes Metab. 2018;20(2):463-467. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813139/ Acesso em: 08 jun. 2022.

BLONDE, Lawrence et al. Gastrointestinal tolerability of extended-release metformin tablets compared to immediate-release metformin tablets: results of a retrospective cohort study. Current Medical Research and Opinion. 2004; 20(4), 565–572.

CONITEC. Protocolo Clínico e Diretrizes Terapêuticas do Diabete Melito Tipo 2. Relatório de recomendação. Ministério da Saúde. Brasília, 2020. Disponível em: http://conitec.gov.br/images/Consultas/Relatorios/2020/20201113_Relatorio_PCDT_565_Diabete_Melito_Tipo_2.pdf Acesso em: 08 jun. 2022.

FUJIOKA, Ken et al. Glycemic control in patients with type 2 diabetes mellitus switched from twice-daily immediate-release metformin to a once-daily extended-release formulation. Clinical Therapeutics. 2003; 25(2), 515–529.

GLIFAGE. Cloridrato de metformina. [Bula]. Merck S/A. Bula para o profissional de saúde. Acesso em: 22 jun. 2022. Disponível em: https://consultas.anvisa.gov.br/#/bulario/q/?nomeProduto=GLIFAGE

GLIFAGE XR. Cloridrato de metformina. [Bula]. Merck S/A. Bula para o profissional de saúde. Acesso em: 22 jun. 2022. Disponível em: https://consultas.anvisa.gov.br/#/bulario/q/?nomeProduto=GLIFAGE%20XR

NICE, National Institute for Health and Care Excellence. Type 2 diabetes in adults: management. NICE guideline [NG28]. Published: 02 December 2015. Disponível em: https://www.nice.org.uk/guidance/ng28 Acesso em: 22 jun. 2022.

TAN, Jixue et al. Long-Acting Metformin Vs. Metformin Immediate Release in Patients With Type 2 Diabetes: A Systematic Review. Front Pharmacol. 2021;12:669814. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165304/ Acesso em: 08 jun. 2022.